Detail Article

Oral and Maxillofacial Pathology Journal / Vol. 4. No. 1. 0000-00: 11 - 15

Expression of IL-1 on Mucosal Cavity’s Chronic Inflammation after Provision of Clarias Batrachus Fish Oil

Ekspresi IL-1 Pada Radang Kronis Mukosa Rongga Mulut Setelah Pemberian Fish Oil Ikan Lele (Clarias Batrachus)

  1. Intan Vallentien Dwi Hariati
    Mahasiswa Pendidikan Dokter Gigi Fakultas Kedokteran Gigi Universitas Airlangga
  2. Theresia Indah Budhy
    Staf Pengajar Fakultas Kedokteran Gigi Universitas Airlangga
  3. istiati
    Staf Pengajar Fakultas Kedokteran Gigi Universitas Airlangga


The presence of cell or tissue damage always followed by inflammatory reactions. Inflammatory process should not persist because it can interfere even inhibit regeneration. An increased circulation of IL-1, IL-6 and TNF-alpha happens in chronic inflammation. IL-1 is granulocytes chemoattractant and has function to localize inflammation. Overexpression of IL-1 can inhibit wound healing so it needs currative treatment to decrease IL-1’s expression. Purpose. To know expression of IL-1 after provision of Clarias batrachus fish oil. Methods. We have used the post test only design in this research. There have been 19 Rattus novergicus as research samples and those were divided into 3 groups, group 1 as control, group 2 has given 10% fish oil and group 2 has given 5% fish oil. Chronic inflammation treated to all samples for three days. The group 1 and 2 given Clarias batrachus fish oil on the third day. We did decapitation on the fourth day to perform Immunohistochemistry staining. The data were tabulated and analyzed statistically used Oneway ANOVA.Result. Group 2 and 3 has lower IL-1 expression than Control group. There is significant difference between groups. Conclusion. Clarias batrachus Fish oil  can lowered IL-1 expression on mucosal cavity’s chronic inflammation.

Keyword: Chronic inflammation, Fish oil Clarias batrachus, IL-1,



Daftar Pustaka

  1. Wang dan Huang, Polyunsaturated Fatty Acids and Inflammation in Obesity. -, Biomed Res Int, 2015.

Visitor Article : 7686

Visitor Download : 1